Impact of COVID-19 on red blood cell rheology

Céline Renoux^{1

2

3

4}, Romain Fort^{2

3

4

5}, Elie Nader^{2

3

4}, Camille Boisson^{2

3

4}, Philippe Joly^{1

2

3

4}, Emeric Stauffer^{2

3

4

6}, Mélanie Robert^{2

3

7}, Sandrine Girard⁸, Agnès Cibiel⁷, Alexandra Gauthier^{2

3

4

9}, Philippe Connes^{2

3

4}

Affiliations

¹ UM Pathologies Métaboliques, Erythrocytaires et Dépistage Périnatal, Service de Biochimie et Biologie Moléculaire Grand-Est, Hospices Civils de Lyon, Lyon, France.
² Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe Biologie Vasculaire et du Globule Rouge, Université Claude Bernard Lyon 1, Villeurbanne, France.
³ Laboratoire d'Excellence "GR-Ex", Paris, France.
⁴ Centre de Référence Constitutif Syndromes Drépanocytaires Majeurs, Thalassémies et Autres Pathologies Rares du Globule Rouge et de l'Erythropoïèse, Hospices Civils de Lyon, Lyon, France.
⁵ Service de Médecine Interne, Hôpital Edouard-Herriot, Lyon, France.
⁶ Service d'Explorations Fonctionnelles Respiratoires - Médecine du sport et de l'activité Physique, Hôpital de la Croix-Rousse, Lyon, France.
⁷ Erytech Pharma, Lyon, France.
⁸ Service d'Hématologie Biologique, Hospices Civils de Lyon, Lyon, France.
⁹ Institut d'Hématologie et d'Oncologie Pédiatrique (IHOPe), Hospices Civils de Lyon, Lyon, France.

PMID: 33410504
DOI: 10.1111/bjh.17306

Clinical Trial

Impact of COVID-19 on red blood cell rheology

Céline Renoux et al. Br J Haematol. 2021 Feb.

. 2021 Feb;192(4):e108-e111.

doi: 10.1111/bjh.17306. Epub 2021 Jan 7.

Authors

Affiliations

¹ UM Pathologies Métaboliques, Erythrocytaires et Dépistage Périnatal, Service de Biochimie et Biologie Moléculaire Grand-Est, Hospices Civils de Lyon, Lyon, France.
² Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe Biologie Vasculaire et du Globule Rouge, Université Claude Bernard Lyon 1, Villeurbanne, France.
³ Laboratoire d'Excellence "GR-Ex", Paris, France.
⁴ Centre de Référence Constitutif Syndromes Drépanocytaires Majeurs, Thalassémies et Autres Pathologies Rares du Globule Rouge et de l'Erythropoïèse, Hospices Civils de Lyon, Lyon, France.
⁵ Service de Médecine Interne, Hôpital Edouard-Herriot, Lyon, France.
⁶ Service d'Explorations Fonctionnelles Respiratoires - Médecine du sport et de l'activité Physique, Hôpital de la Croix-Rousse, Lyon, France.
⁷ Erytech Pharma, Lyon, France.
⁸ Service d'Hématologie Biologique, Hospices Civils de Lyon, Lyon, France.
⁹ Institut d'Hématologie et d'Oncologie Pédiatrique (IHOPe), Hospices Civils de Lyon, Lyon, France.

PMID: 33410504
DOI: 10.1111/bjh.17306

No abstract available

Keywords: COVID-19; aggregation; blood viscosity; deformability; red blood cell.

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References

1. Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse P-R, Fobker M, et al. Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. 2020:1-13. https://doi.org/10.1007/s10456-020-09753-7.
1. Bateman RM, Jagger JE, Sharpe MD, Ellsworth ML, Mehta S, Ellis CG. Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. Am J Physiol Heart Circ Physiol. 2001;280(6):H2848-H2856.
1. Bateman RM, Sharpe MD, Jagger JE, Ellis CG. Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries. Crit Care. 2015;19:389.
1. Reggiori G, Occhipinti G, De Gasperi A, Vincent J-L, Piagnerelli M. Early alterations of red blood cell rheology in critically ill patients. Crit Care Med. 2009;37(12):3041-6.
1. Baskurt OK, Temiz A, Meiselman HJ. Red blood cell aggregation in experimental sepsis. J Lab Clin Med. 1997;130(2):183-90.

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Impact of COVID-19 on red blood cell rheology

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Impact of COVID-19 on red blood cell rheology

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