Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr;48(2):120-134.
doi: 10.1111/iji.12526. Epub 2021 Jan 7.

Immunogenetics of xenotransplantation

Affiliations
Review

Immunogenetics of xenotransplantation

Marco Carvalho-Oliveira et al. Int J Immunogenet. 2021 Apr.

Abstract

Xenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs. The introduced genetic modifications showed to be efficient in prolonging xenograft survival. In this review, we focus on the type of immune responses that may target xeno-organs after transplantation and promising immunogenetic modifications that show a beneficial effect in ameliorating or eliminating harmful xenogeneic immune responses. Increasing histocompatibility of xenografts by eliminating genetic discrepancies between species will pave their way into clinical application.

Keywords: gene therapy; histocompatibility; immunogenetics; immunology; organ bioengineering; xenotransplantation.

PubMed Disclaimer

References

REFERENCES

    1. Abe, M., Cheng, J., Qi, J., Glaser, R. M., Thall, A. D., Sykes, M., & Yang, Y. G. (2002). Elimination of porcine hemopoietic cells by macrophages in mice. The Journal of Immunology, 168(2), 621-628. https://doi.org/10.4049/jimmunol.168.2.621
    1. Adams, A. B., Kim, S. C., Martens, G. R., Ladowski, J. M., Estrada, J. L., Reyes, L. M., Breeden, C., Stephenson, A., Eckhoff, D. E., Tector, M., & Tector, A. J. (2018). Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival. Annals of Surgery, 268(4), 564-573. https://doi.org/10.1097/SLA.0000000000002977
    1. Ayares, D., Vaught, T., Ball, S., Kuravi, K., Morrill, B., Monahan, J., Walters, A., Ramsoondar, J., Kietzmann, C., Ferris, H., Parab, S., Dai, Y., & Phelps, C. (2013). Genetic engineering of source pigs for xenotransplantation: Progress and prospects. Xenotransplantation, 20, 361-361. https://doi.org/10.1111/xen.12060_22
    1. Bähr, A., Käser, T., Kemter, E., Gerner, W., Kurome, M., Baars, W., Herbach, N., Witter, K., Wünsch, A., Talker, S. C., Kessler, B., Nagashima, H., Saalmüller, A., Schwinzer, R., Wolf, E., & Klymiuk, N. (2016). Ubiquitous LEA29Y expression blocks T cell co-stimulation but permits sexual reproduction in genetically modified pigs. PLoS One, 11(5), e0155676. https://doi.org/10.1371/journal.pone.0155676
    1. Benda, B., Karlsson-Parra, A., Ridderstad, A., & Korsgren, O. (1996). Xenograft rejection of porcine islet-like cell clusters in immunoglobulin- or Fc-receptor gamma-deficient mice. Transplantation, 62(9), 1207-1211. https://doi.org/10.1097/00007890-199611150-00003

Substances

LinkOut - more resources