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. 2021 Feb;18(2):e2000827.
doi: 10.1002/cbdv.202000827. Epub 2021 Jan 7.

Purification, Characterization, and Antiproliferative Activity of a Single-Chain Lectin from Vicia palaestina (Fabaceae) Seeds

Youssef Elamine  1 , Verenice Torres-Salas  2 , Alima Messai  1 , Julio Girón-Calle  1 , Manuel Alaiz  1 , Javier Vioque  1
Affiliations

Purification, Characterization, and Antiproliferative Activity of a Single-Chain Lectin from Vicia palaestina (Fabaceae) Seeds

Youssef Elamine et al. Chem Biodivers. 2021 Feb.

Abstract

Vicia palaestina Boiss. is an annual herb that grows in dry areas of eastern Mediterranean countries. It belongs to section Cracca subgenus Vicilla, which is characterized by having a high content in the non-protein amino acid canavanine. The seeds from some of these vetches are also rich in lectins. The purification and characterization of a single-chain lectin from the seeds of V. palaestina is described here. This lectin was the most abundant protein in albumin extracts. It has affinity for the glycoconjugate N-acetylgalactosamine and inhibits proliferation of the cancerous Caco-2 and THP-1 cell lines. In addition to their high nutritional value, the seeds from V. palaestina represent a source of lectins with health promoting and pharmacological potential because of their antiproliferative activity.

Keywords: N-acetylgalactosamine; V. palaestina; antiproliferative activity; seed lectin.

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References

    1. V. Caracuta, M. Weinstein-Evron, D. Kaufman, R. Yeshurun, J. Silvent, E. Boaretto, ‘14,000-year-old seeds indicate the Levantine origin of the lost progenitor of faba bean’, Sci. Rep. 2016, 6, 37399; doi: 10.1038/srep37399.
    1. S. Nagel, R. Matic, G. Kirby, ‘Vetch in Australian farming systems’, Eyre Peninsula Farm. Syst. 2011, 71-72.
    1. C. Megías, I. Cortés-Giraldo, M. Alaiz, J. Girón-Calle, J. Vioque, ‘Nutritional characteristics of seed protein in 16 Vicia species belonging to subgenus Vicilla’, SDRP J. Food Sci. Technol. 2016, 1, 1-9.
    1. M. Muzquiz, A. Varela, C. Burbano, C. Cuadrado, E. Guillamon, M. M. Pedrosa, ‘Bioactive compounds in legumes: pronutritive and antinutritive actions. Implications for nutrition and health’, Phytochem. Rev. 2012, 11, 227-244.
    1. C. Megías, I. Cortés-Giraldo, J. Girón-Calle, M. Aliaz, J. Vioque, ‘Characterization of Vicia (Fabaceae) seed water extracts with potential immunomodulatory and cell antiproliferative activities’, J. Food Biochem. 2018, 42, article number e12578.

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