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Review
. 2021 Jan 5;134(2):143-150.
doi: 10.1097/CM9.0000000000001320.

Pandemic of the aging society - sporadic cerebral small vessel disease

Affiliations
Review

Pandemic of the aging society - sporadic cerebral small vessel disease

Alexander Yuk Lun Lau et al. Chin Med J (Engl). .

Abstract

Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Three-dimensional rotational angiography (3DRA) of the right middle cerebral artery showing steno-occlusion of the perforator ostium (A, white arrow) possibly causing an acute infarct in the right corona radiata as illustrated by the MR diffusion-weighted imaging (B). Of note, the time-of-flight MR angiogram did not reveal any significant intracranial atherosclerotic disease (C). MR: Magnetic resonance.
Figure 2
Figure 2
Three-dimensional rotational angiography (3DRA) of the left middle cerebral artery showing possible perforator stenosis (A, white arrowheads) in a patient with white matter hyperintensities in T2 MRI (B). (C) Follow-up 3DRA showed possible regression in perforator stenosis (white arrows) after 1 year of intensive medical therapy. MRI: Magnetic resonance imaging.

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