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. 2021 Feb;78(2):713-717.
doi: 10.1007/s00284-020-02330-7. Epub 2021 Jan 7.

Membrane Depolarization Sensitizes Pseudomonas aeruginosa Against Tannic Acid

Md Aashique  1 , Amrita Roy  2 , Rekha Yamini Kosuru  1 , Soumen Bera  3
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Membrane Depolarization Sensitizes Pseudomonas aeruginosa Against Tannic Acid

Md Aashique et al. Curr Microbiol. 2021 Feb.

Abstract

The use of dietary polyphenols as antimicrobial agents has gained immense popularity in recent years, although few of them-like tannic acid has limited use in this field of research; one of the main reasons is its restricted access through the bacterial membrane. Dissipating the bacterial membrane potential with a sub-lethal dosage of the protonophore, carbonyl cyanide m-chlorophenyl hydrazone, enhanced the tannic acid-cytotoxicity with subsequent inhibition of aerobic respiration in Pseudomonas aeruginosa strains which otherwise exhibited a minimum response to tannic acid. However, ascorbic acid, an antioxidant and bacterial membrane-stabilizing compound, had rescued the cells from both tannic acid- and CCCP-mediated lethality. The results suggested that dispersing the membrane potential with a protonophore can enhance the antibacterial properties of tannic acid.

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