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Review
. 2021 May;58(5):2183-2201.
doi: 10.1007/s12035-020-02232-6. Epub 2021 Jan 7.

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

Lijun Dai  1 , Li Zou  1 , Lanxia Meng  1 , Guifen Qiang  2 , Mingmin Yan  1 , Zhentao Zhang  3
Affiliations
Review

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

Lijun Dai et al. Mol Neurobiol. 2021 May.

Abstract

Cholesterol is an indispensable component of the cell membrane and plays vital roles in critical physiological processes. Brain cholesterol accounts for a large portion of total cholesterol in the human body, and its content must be tightly regulated to ensure normal brain function. Disorders of cholesterol metabolism in the brain are linked to neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other atypical cognitive deficits that arise at old age. However, the specific role of cholesterol metabolism disorder in the pathogenesis of neurodegenerative diseases has not been fully elucidated. Statins that are a class of lipid-lowering drugs have been reported to have a positive effect on neurodegenerative diseases. Herein, we reviewed the physiological and pathological conditions of cholesterol metabolism and discussed the possible mechanisms of cholesterol metabolism and statin therapy in neurodegenerative diseases.

Keywords: Alzheimer’s disease (AD); Cholesterol metabolism; Neurodegenerative diseases; Parkinson’s disease (PD); Statin therapy.

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References

    1. Dietschy JM, Turley SD (2004) Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45:1375–1397. https://doi.org/10.1194/jlr.R400004-JLR200 - DOI - PubMed
    1. Vance JE (2012) Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases. Dis Model Mech 5:746–755. https://doi.org/10.1242/dmm.010124 - DOI - PubMed - PMC
    1. Berg JM, Tymoczko JL, Stryer L (2002) The complex regulation of cholesterol biosynthesis takes place at several levels. In: Biochemistry, 5th edn. W.H. Freeman, New York
    1. Nieweg K, Schaller H, Pfrieger FW (2009) Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats. J Neurochem 109:125–134. https://doi.org/10.1111/j.1471-4159.2009.05917.x - DOI - PubMed
    1. Saher G, Brügger B, Lappe-Siefke C et al (2005) High cholesterol level is essential for myelin membrane growth. Nat Neurosci 8:468–475. https://doi.org/10.1038/nn1426 - DOI - PubMed

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