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. 1977 Sep 28;38(3):149-61.
doi: 10.1007/BF00293649.

Mutagenicity studies with praziquantel, a new anthelmintic drug: tissue-, host-, and urine-mediated mutagenicity assays

J Obermeier, H Frohberg

Mutagenicity studies with praziquantel, a new anthelmintic drug: tissue-, host-, and urine-mediated mutagenicity assays

J Obermeier et al. Arch Toxicol. .

Abstract

Praziquantel, a new anthelmintic drug with activity against all species of schistosomes pathogenic to man, and against a wide range of Cestodes, was tested for mutagenic potential. For the detection of both base substitutions and frameshift mutations, Salmonella typhimurium TA 100 and TA 98 were used as tester strains. Using the plate assay with and without added S-9, host-mediated assay and urine-mediated assay without and after incubation with beta-glucuronidase/arylsulfatase, no mutagenic activity could be detected.

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References

    1. Proc Natl Acad Sci U S A. 1974 Mar;71(3):737-41 - PubMed
    1. J Biol Chem. 1956 Jan;218(1):97-106 - PubMed
    1. Z Parasitenkd. 1977 Jul 21;52(2):129-50 - PubMed
    1. Cancer Lett. 1975 Nov;1(2):69-74 - PubMed
    1. Mutat Res. 1975 Dec;31(6):347-64 - PubMed

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