Sex matters: COVID-19 in kidney transplantation

doi:10.1016/j.kint.2020.12.020

. 2021 Mar;99(3):555-558.

doi: 10.1016/j.kint.2020.12.020. Epub 2021 Jan 5.

Sex matters: COVID-19 in kidney transplantation

Affiliations

¹ Division of Nephrology, Department of Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
² Department: Surgery, University of Chicago, Chicago, Illinois, USA.
³ College of Nursing and Health Professionals, Drexel University, Philadelphia, Pennsylvania, USA.
⁴ Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
⁵ Department of Pediatrics, Montreal Children's Hospital of the McGill University Health Centre, Montreal, Quebec, Canada; Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada.
⁶ Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Department of Laboratory Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Alberta Precision Laboratories, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada.
⁷ Department of Medicine/Nephrology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁸ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁹ Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.
¹⁰ Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada; Department of Pediatrics and Surgery, University of Alberta, Edmonton, Alberta, Canada; Department of Medical Microbiology/Immunology, University of Alberta, Edmonton, Alberta, Canada; Department of Laboratory Medicine/Pathology, University of Alberta, Edmonton, Alberta, Canada.
¹¹ School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
¹² Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Division of Nephrology, Department of Medicine, McGill University, Montreal, Quebec, Canada; Centre for Outcomes Research, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: ruth.sapir-pichhadze@mcgill.ca.

PMID: 33412163
PMCID: PMC7783460
DOI: 10.1016/j.kint.2020.12.020

Sex matters: COVID-19 in kidney transplantation

Amanda J Vinson et al. Kidney Int. 2021 Mar.

. 2021 Mar;99(3):555-558.

doi: 10.1016/j.kint.2020.12.020. Epub 2021 Jan 5.

Authors

Affiliations

¹ Division of Nephrology, Department of Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
² Department: Surgery, University of Chicago, Chicago, Illinois, USA.
³ College of Nursing and Health Professionals, Drexel University, Philadelphia, Pennsylvania, USA.
⁴ Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
⁵ Department of Pediatrics, Montreal Children's Hospital of the McGill University Health Centre, Montreal, Quebec, Canada; Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada.
⁶ Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Department of Laboratory Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Alberta Precision Laboratories, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada.
⁷ Department of Medicine/Nephrology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁸ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
⁹ Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.
¹⁰ Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada; Department of Pediatrics and Surgery, University of Alberta, Edmonton, Alberta, Canada; Department of Medical Microbiology/Immunology, University of Alberta, Edmonton, Alberta, Canada; Department of Laboratory Medicine/Pathology, University of Alberta, Edmonton, Alberta, Canada.
¹¹ School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
¹² Canadian Donation and Transplantation Research Program, Edmonton, Alberta, Canada; Division of Nephrology, Department of Medicine, McGill University, Montreal, Quebec, Canada; Centre for Outcomes Research, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: ruth.sapir-pichhadze@mcgill.ca.

PMID: 33412163
PMCID: PMC7783460
DOI: 10.1016/j.kint.2020.12.020

No abstract available

Keywords: COVID-19; gender; sex; transplantation.

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Figures

**Figure 1**
**The roles of sex, gender, and transplantation in coronavirus disease 2019 (COVID-19).** ACE2, angiotensin-converting enzyme 2; PD, pharmacodynamics; PG, pharmacogenomics; PK, pharmacokinetics; TLR, toll-like receptor; TMPRSS2, transmembrane protease serine 2.

**Figure 2**
**Summary of proposed policy changes, targeted stakeholders, and benefits to the individual patient**.

See this image and copyright information in PMC

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COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative.
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A multi-faceted approach to sex and gender equity in solid organ transplantation: The Women in Transplantation Initiative of The Transplantation Society.
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References

1. Elias M., Pievani D., Randoux C., et al. COVID-19 infection in kidney transplant recipients: disease incidence and clinical outcomes. J Am Soc Nephrol. 2020;31:2413–2423. - PMC - PubMed
1. Jager K.J., Kramer A., Chesnaye N.C., et al. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney Int. 2020;98:1540–1548. - PMC - PubMed
1. Marquez E.J., Trowbridge J., Kuchel G.A., et al. The lethal sex gap: COVID-19. Immun Ageing. 2020;17:13. - PMC - PubMed
1. Klein S.L., Dhakal S., Ursin R.L., et al. Biological sex impacts COVID-19 outcomes. PLoS Pathog. 2020;16 - PMC - PubMed
1. Bastard P., Rosen L.B., Zhang Q., et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 - PMC - PubMed

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[1] Elias M., Pievani D., Randoux C., et al. COVID-19 infection in kidney transplant recipients: disease incidence and clinical outcomes. J Am Soc Nephrol. 2020;31:2413–2423. - PMC - PubMed

[2] Elias M., Pievani D., Randoux C., et al. COVID-19 infection in kidney transplant recipients: disease incidence and clinical outcomes. J Am Soc Nephrol. 2020;31:2413–2423. - PMC - PubMed

[3] Jager K.J., Kramer A., Chesnaye N.C., et al. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney Int. 2020;98:1540–1548. - PMC - PubMed

[4] Jager K.J., Kramer A., Chesnaye N.C., et al. Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney Int. 2020;98:1540–1548. - PMC - PubMed

[5] Marquez E.J., Trowbridge J., Kuchel G.A., et al. The lethal sex gap: COVID-19. Immun Ageing. 2020;17:13. - PMC - PubMed

[6] Marquez E.J., Trowbridge J., Kuchel G.A., et al. The lethal sex gap: COVID-19. Immun Ageing. 2020;17:13. - PMC - PubMed

[7] Klein S.L., Dhakal S., Ursin R.L., et al. Biological sex impacts COVID-19 outcomes. PLoS Pathog. 2020;16 - PMC - PubMed

[8] Klein S.L., Dhakal S., Ursin R.L., et al. Biological sex impacts COVID-19 outcomes. PLoS Pathog. 2020;16 - PMC - PubMed

[9] Bastard P., Rosen L.B., Zhang Q., et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 - PMC - PubMed

[10] Bastard P., Rosen L.B., Zhang Q., et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 - PMC - PubMed

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Sex matters: COVID-19 in kidney transplantation

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Sex matters: COVID-19 in kidney transplantation

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