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Review
. 2021 Jan 7;20(1):9.
doi: 10.1186/s12933-020-01200-7.

Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

Bao Sun  1   2 , Zhiying Luo  3   4 , Jiecan Zhou  5
Affiliations
Review

Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

Bao Sun et al. Cardiovasc Diabetol. .

Abstract

Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.

Keywords: Diabetes mellitus; Diabetic macrovascular and microvascular complications; Glycemic variability; Therapeutic strategies.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Potential mechanisms of glycemic variability in diabetic macrovascular and microvascular
See this image and copyright information in PMC

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