Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
- PMID: 33413740
- PMCID: PMC7791602
- DOI: 10.2807/1560-7917.ES.2020.26.1.2002106
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
Erratum in
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Addendum for Euro Surveill. 2021;26(1).Euro Surveill. 2021 Jan;26(3):210121a. doi: 10.2807/1560-7917.ES.2021.26.3.210121a. Euro Surveill. 2021. PMID: 33478624 Free PMC article. No abstract available.
Abstract
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
Keywords: 20B/501Y.V1; COVID-19; N501Y; SARS-CoV-2; United Kingdom; VOC-202012/01; fitness; lineage B.1.1.7; spike protein; transmissibility.
Conflict of interest statement
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