Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Feb;42(2):345-52.

Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1)

N P Anagnou  1 , S E Antonarakis, S J O'Brien, W S Modi, A W Nienhuis
Affiliations
Comparative Study

Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1)

N P Anagnou et al. Am J Hum Genet. 1988 Feb.

Abstract

The human dihydrofolate reductase (DHFR) gene family comprises one functional gene and at least four intronless processed pseudogenes. The functional DHFR gene is on chromosome 5, and DHFRP4 is on chromosome 3. Using in situ hybridization, we have now localized the functional DHFR gene to the region q11.1-q13.3 on chromosome 5. By genomic DNA analysis of a panel of human X rodent somatic-cell hybrids, we determined the chromosomal assignment of the DHFRP1 pseudogene to chromosome 18 and that of the DHFRP2 pseudogene to chromosome 6. The DHFRP1 pseudogene exhibits a novel form of polymorphism in humans in that it is present in the DNA of some individuals and absent in that of others. We investigated the racial distribution of this pseudogene in five racial groups. The allelic frequency as defined by analysis of 180 chromosomes was found to be 94% in Mediterraneans, 77% in Asian Indians, 67% in Chinese, 57% in Southeast Asians, and 32% in American blacks. These data suggest that the transposition of this "perfect" pseudogene occurred prior to the inception of the human racial groups.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Comparative map for mice and humans.
    Nadeau JH, Davisson MT, Doolittle DP, Grant P, Hillyard AL, Kosowsky MR, Roderick TH. Nadeau JH, et al. Mamm Genome. 1992;3(9):480-536. doi: 10.1007/BF00778825. Mamm Genome. 1992. PMID: 1392257 Review. No abstract available.
  • The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.
    McEntee G, Minguzzi S, O'Brien K, Ben Larbi N, Loscher C, O'Fágáin C, Parle-McDermott A. McEntee G, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15157-62. doi: 10.1073/pnas.1103605108. Epub 2011 Aug 26. Proc Natl Acad Sci U S A. 2011. PMID: 21876184 Free PMC article.
  • Gene copy-number polymorphism caused by retrotransposition in humans.
    Schrider DR, Navarro FC, Galante PA, Parmigiani RB, Camargo AA, Hahn MW, de Souza SJ. Schrider DR, et al. PLoS Genet. 2013;9(1):e1003242. doi: 10.1371/journal.pgen.1003242. Epub 2013 Jan 24. PLoS Genet. 2013. PMID: 23359205 Free PMC article.
  • Mouse chromosome 13.
    Justice MJ, Stephenson DA. Justice MJ, et al. Mamm Genome. 1992;3 Spec No:S195-205. doi: 10.1007/BF00648431. Mamm Genome. 1992. PMID: 1498432 Review. No abstract available.
  • Mouse chromosome 13.
    Justice MJ, Stephenson DA. Justice MJ, et al. Mamm Genome. 1991;1 Spec No:S205-20. doi: 10.1007/BF00656494. Mamm Genome. 1991. PMID: 1799801 Review. No abstract available.
See all "Cited by" articles

References

    1. Science. 1969 Aug 22;165(3895):762-8 - PubMed
    1. Am J Hum Genet. 1985 Nov;37(6):1192-205 - PubMed
    1. Chromosoma. 1981;83(3):431-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7435-9 - PubMed
    1. Nature. 1983 Apr 28;302(5911):839-42 - PubMed

Publication types

Substances

LinkOut - more resources