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Review
. 2020 Dec 1;10(12):4066-4084.
eCollection 2020.

Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Yongting Lai  1 , Hairong Huang  2 , Mubalake Abudoureyimu  3 , Xinrong Lin  3 , Chuan Tian  3 , Ting Wang  3 , Xiaoyuan Chu  1   3 , Rui Wang  1   3
Affiliations
Review

Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Yongting Lai et al. Am J Cancer Res. .

Abstract

Reprogramming of metabolism is one of the hallmarks of cancer, among which glucose metabolism dysfunction is the most prominent feature. The glucose metabolism of tumor cells is significantly different from that of normal cells. Glucose metabolism reprogramming of hepatocellular carcinoma (HCC) has become an important research hotspot in the field of HCC, a variety of tumor metabolic interventions have been applied clinically. Moreover, various Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding (lncRNAs) as well as circular RNAs (circRNAs), have recently been proved to play potential roles in glucose metabolism. This review summarizes the effects of ncRNAs on HCC that participate in glucose metabolism and discuss the related mechanisms to find potential and effective targeted treatments for HCC.

Keywords: Hepatocellular carcinoma; circular RNAs; glucose metabolism; glycolysis; long non-coding RNAs; microRNAs; non-coding RNA.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
A. The biogenesis of ncRNAs. miRNAs are transcribed into pri-miRNA under the help of RNA Polymerase II, pri-miRNA is processed into a pre-miRNA by Drosha/DGCR8 in the nucleus, and then transported to the cytoplasm via Exportin-5, pre-miRNA is further cleaved by Dicer to form mature miRNA. lncRNAs are transcribed by RNA Polymerase II or III. B. CircRNAs formed by exon circularization.
Figure 2
Figure 2
Glycolysis pathway, PPP and gluconeogenesis pathway of HCC, and the role of ncRNAs in glucose metabolism via regulating rate-controlling enzyme and GLUT.
Figure 3
Figure 3
NcRNAs may play an important role in regulating glucose metabolism of HCC through different signal pathways and mechanisms.
See this image and copyright information in PMC

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