Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 1;10(12):4066-4084.
eCollection 2020.

Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Yongting Lai  1 , Hairong Huang  2 , Mubalake Abudoureyimu  3 , Xinrong Lin  3 , Chuan Tian  3 , Ting Wang  3 , Xiaoyuan Chu  1   3 , Rui Wang  1   3
Affiliations
Review

Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Yongting Lai et al. Am J Cancer Res. .

Abstract

Reprogramming of metabolism is one of the hallmarks of cancer, among which glucose metabolism dysfunction is the most prominent feature. The glucose metabolism of tumor cells is significantly different from that of normal cells. Glucose metabolism reprogramming of hepatocellular carcinoma (HCC) has become an important research hotspot in the field of HCC, a variety of tumor metabolic interventions have been applied clinically. Moreover, various Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding (lncRNAs) as well as circular RNAs (circRNAs), have recently been proved to play potential roles in glucose metabolism. This review summarizes the effects of ncRNAs on HCC that participate in glucose metabolism and discuss the related mechanisms to find potential and effective targeted treatments for HCC.

Keywords: Hepatocellular carcinoma; circular RNAs; glucose metabolism; glycolysis; long non-coding RNAs; microRNAs; non-coding RNA.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
A. The biogenesis of ncRNAs. miRNAs are transcribed into pri-miRNA under the help of RNA Polymerase II, pri-miRNA is processed into a pre-miRNA by Drosha/DGCR8 in the nucleus, and then transported to the cytoplasm via Exportin-5, pre-miRNA is further cleaved by Dicer to form mature miRNA. lncRNAs are transcribed by RNA Polymerase II or III. B. CircRNAs formed by exon circularization.
Figure 2
Figure 2
Glycolysis pathway, PPP and gluconeogenesis pathway of HCC, and the role of ncRNAs in glucose metabolism via regulating rate-controlling enzyme and GLUT.
Figure 3
Figure 3
NcRNAs may play an important role in regulating glucose metabolism of HCC through different signal pathways and mechanisms.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. - PubMed
    1. Maluccio M, Covey A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 2012;62:394–399. - PubMed
    1. Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH, Marrero JA. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358–380. - PubMed
    1. Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression. Science. 2020;368:w5473. - PMC - PubMed
    1. David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature. 2010;463:364–368. - PMC - PubMed

LinkOut - more resources