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Review
. 2020 Dec 1;10(12):4085-4097.
eCollection 2020.

The role of Pim kinase in immunomodulation

Zhaoyun Liu  1 , Mei Han  1 , Kai Ding  1 , Rong Fu  1
Affiliations
Review

The role of Pim kinase in immunomodulation

Zhaoyun Liu et al. Am J Cancer Res. .

Abstract

Pim kinase, which has three isozymes (Pim-1, Pim-2 and Pim-3), is a serine/threonine kinase abnormally expressed in many cancers. High Pim kinase expression has been recognized to be associated with disease progression and prognosis. It is well accepted that Pim kinase is considered a clinical biomarker and potential therapeutic target for tumor cell. In recent years, researches verified the role of Pim kinase in immunomodulation. The mechanisms by which Pim kinase modulates the immune microenvironment and regulates immune cells, as well as the effects of Pim kinase inhibitors on immunity, have not been systematically described. This review comprehensively focuses on the current research status of Pim kinase pathways and the immune regulation.

Keywords: PI3K/Akt/mTOR; Pim kinase; cancer; immune; inhibitors.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Pim kinase signaling. Pim kinase is involved in apoptosis and proliferation, cell cycle regulation, migration, energy metabolism, transcription and splicing.
Figure 2
Figure 2
Regulation of immune cells by Pim kinase.
See this image and copyright information in PMC

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