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Review
. 2021 Mar;23(3):529-537.
doi: 10.1111/jch.14155. Epub 2021 Jan 7.

Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension

Huynh Van Minh  1 , Hoang Anh Tien  1 , Cao Thuc Sinh  2 , Doan Chi Thang  3 , Chen-Huan Chen  4   5   6 , Jam Chin Tay  7 , Saulat Siddique  8 , Tzung-Dau Wang  9   10 , Guru Prasad Sogunuru  11   12 , Yook-Chin Chia  13   14 , Kazuomi Kario  15
Affiliations
Review

Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension

Huynh Van Minh et al. J Clin Hypertens (Greenwich). 2021 Mar.

Abstract

Insulin resistance (IR), a metabolic risk factor, is linked to the pathogenetic mechanism of primary hypertension. Detecting IR in the patients with hypertension will help to predict and stratify the added cardiovascular risk, institute appropriate IR management, and manage hypertension optimally. There are many methods for assessing IR, each with distinct advantages and disadvantages. The euglycemic insulin clamp and intravenous glucose tolerance test, gold standards for measuring IR, are used in research but not in clinical practice. Homeostatic model assessment (HOMA-IR), a method for assessing β-cell function and IR, is frequently applied presently, particularly in Asia. Besides, the triglyceride-glucose index (TyG) first published by South American authors showed a good correlation with the insulin clamp technique and HOMA-IR index. This simple, convenient, and low-cost TyG index is of research interest in many countries in Asia and can be used to screen for IR in the Asian hypertensive community.

Keywords: Asia patients; hypertension; insulin resistance.

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Conflict of interest statement

CH Chen reports personal fees from Novartis, Sanofi, Daiichi Sankyo, SERVIER, and Boehringer Ingelheim Pharmaceuticals, Inc S Siddique has received honoraria from Bayer, Novartis, Pfizer, ICI, and Servier; and travel, accommodation, and conference registration support from Hilton Pharma, Atco Pharmaceutical, Highnoon Laboratories, Horizon Pharma and ICI. All other authors report no potential conflicts of interest in relation to this article.

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