Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Jun;58(6):671-685.
doi: 10.1007/s00592-020-01648-9. Epub 2021 Jan 8.

The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis

Yue You #  1 , Zhizhen Liu #  2   3   4   5 , Yannan Chen  6 , Ying Xu  6   7   8   9 , Jiawei Qin  6 , Shuai Guo  6 , Jia Huang  6   8   9 , Jing Tao  6   7   8   9
Affiliations
Meta-Analysis

The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis

Yue You et al. Acta Diabetol. 2021 Jun.

Abstract

Aims: Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies.

Methods: We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16.

Results: A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I2=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I2=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I2=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I2=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I2=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I2=91.2%).

Conclusion: Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.

Keywords: Dementia; Mild cognitive impairment; Prevalence; Type 2 diabetes mellitus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

Reference

    1. Saeedi P, Petersohn I, Salpea P et al (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract 157:107843. https://doi.org/10.1016/j.diabres.2019.107843 - DOI - PubMed
    1. Reijmer YD, Brundel M, de Bresser J et al (2013) Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: a diffusion tensor imaging study. Diabetes Care 36(1):137–144. https://doi.org/10.2337/dc12-0493 - DOI - PubMed
    1. Geijselaers SLC, Sep SJS, Stehouwer CDA, Biessels GJ (2015) Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. Lancet Diabetes Endocrinol 3(1):75–89. https://doi.org/10.1016/S2213-8587(14)70148-2 - DOI - PubMed
    1. Koekkoek PS, Kappelle LJ, van den Berg E, Rutten GE, Biessels GJ (2015) Cognitive function in patients with diabetes mellitus: guidance for daily care. Lancet Neurol 14(3):329–340. https://doi.org/10.1016/S1474-4422(14)70249-2 - DOI - PubMed
    1. Langa KM, Levine DA (2014) The diagnosis and management of mild cognitive impairment: a clinical review. JAMA 312(23):2551–2561. https://doi.org/10.1001/jama.2014.13806 - DOI - PubMed - PMC

LinkOut - more resources