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. 2021 Dec;15(6):933-941.
doi: 10.1007/s11764-020-00986-5. Epub 2021 Jan 8.

Important factors associated with sick leave after allogeneic haematopoietic stem cell transplantation-a 1-year prospective study

Linda Eriksson  1   2 , Agneta Wennman-Larsen  3   4 , Karin Bergkvist  5   4 , Per Ljungman  6   7 , Jeanette Winterling  5   8
Affiliations

Important factors associated with sick leave after allogeneic haematopoietic stem cell transplantation-a 1-year prospective study

Linda Eriksson et al. J Cancer Surviv. 2021 Dec.

Abstract

Purpose: This study examines sick leave (SL) and factors associated with full-time SL 1 year after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in patients of working age from 2009 to 2016 (n = 122).

Methods: Questionnaire data were collected on admission to the allo-HSCT unit, at 7 months and 1 year after allo-HSCT. Associations between factors and SL were analysed using logistic regression analyses.

Results: One year after allo-HSCT, 76% of participants were on SL, with 36% on full-time SL. In univariable analyses, chronic graft-versus-host-disease (cGvHD) (OR 3.07; 95% CI 1.34-7.07; p = 0.01), having symptoms of depression at 7 months (OR 4.81; 95% CI 1.69-13.69; p = 0.00) and low levels of vocational satisfaction at 7 months after treatment (OR 3.27; 95% CI 1.27-8.41; p = 0.01) were associated with full-time SL 1 year after allo-HSCT. cGvHD (OR 3.43; 95% CI 1.35-8.73; p = 0.01) and having symptoms of depression at 7 months after allo-HSCT (OR 3.37; 95% CI 1.2-11.58; p = 0.02) remained significant in multivariable analysis.

Conclusion: The majority of allo-HSCT survivors were on SL 1 year after treatment, and cGvHD, low vocational satisfaction and depressive symptoms were associated with full-time SL 1 year after allo-HSCT.

Implications for cancer survivors: Healthcare professionals need to be observant of and manage the consequences of cGvHD and patients' symptoms of depression in order to support them appropriately in their return-to-work process.

Keywords: Allogeneic haematopoietic stem cell transplantation; Return to work; Sick leave; Sickness absence.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Enrolment of study participants
Fig. 2
Fig. 2
Proportions of participants (%) on SL at the different time points (n = 122)
See this image and copyright information in PMC

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