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. 2021 Feb 8;39(2):138-140.
doi: 10.1016/j.ccell.2020.12.019. Epub 2021 Jan 7.

Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells

David M Davies  1 , John Maher  2
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Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells

David M Davies et al. Cancer Cell. .
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Abstract

CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR T cell recruitment to lung tumors, boosting therapeutic impact in combination with anti-PD-L1.

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Conflict of interest statement

Declaration of interests J.M. is CSO, scientific founder, and shareholder of Leucid Bio. D.M.D. is a consultant for Leucid Bio.

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