Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jan 7;81(1):8-9.
doi: 10.1016/j.molcel.2020.12.031.

Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated σ-Factor Tethering

Jason Saba  1 , Xinyun Cao  1 , Robert Landick  2
Affiliations
Free article
Comment

Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated σ-Factor Tethering

Jason Saba et al. Mol Cell. .
Free article

Abstract

Travis et al. (2020) reveal how Francisella tularensis uses stress-induced ppGpp to activate its virulent pathogenesis program by tethering an αCTD-DNA organizer (PigR) to a σ-organizing heterodimer (MglA-SspA), highlighting the remarkable diversity of transcriptional mechanisms in under-studied bacteria.

PubMed Disclaimer

Comment on

  • Structural Basis for Virulence Activation of Francisella tularensis.
    Travis BA, Ramsey KM, Prezioso SM, Tallo T, Wandzilak JM, Hsu A, Borgnia M, Bartesaghi A, Dove SL, Brennan RG, Schumacher MA. Travis BA, et al. Mol Cell. 2021 Jan 7;81(1):139-152.e10. doi: 10.1016/j.molcel.2020.10.035. Epub 2020 Nov 19. Mol Cell. 2021. PMID: 33217319 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources