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. 2021 Jan 7;184(1):3-9.
doi: 10.1016/j.cell.2020.12.020.

The Rise of Molecular Glues

Stuart L Schreiber  1
Affiliations
Free article

The Rise of Molecular Glues

Stuart L Schreiber. Cell. .
Free article

Abstract

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.

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Conflict of interest statement

Declaration of Interests S.L.S. is a shareholder and serves on the Board of Directors of Jnana Therapeutics; is a shareholder of Forma Therapeutics and Decibel Therapeutics; is a shareholder and advises Kojin Therapeutics, Kisbee Therapeutics, Exo Therapeutics, and Eikonizo Therapeutics; serves on the scientific advisory boards of Eisai Co., Ltd., Ono Pharma Foundation, Biogen, Inc., F-Prime Capital Partners, and the Board of Advisers of the Genomics Institute of the Novartis Research Foundation; and is a Novartis Faculty Scholar.

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