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. 2021 Jan 7;28(1):1-2.
doi: 10.1016/j.stem.2020.12.007.

One Big Step to a Neuron, Two Small Steps for miRNAs

Joseph R Herdy  1 , Lukas Karbacher  2 , Jerome Mertens  3
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One Big Step to a Neuron, Two Small Steps for miRNAs

Joseph R Herdy et al. Cell Stem Cell. .
Free article

Abstract

Direct cell fate conversion of human somatic cells into induced neurons (iNs) is often regarded as a highly concerted one-step process. In this issue of Cell Stem Cell, Cates et al. (2021) dissect the iN conversion trajectory into two largely independent steps and identify key players at each stage.

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