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Comment
. 2021 Jan 7;28(1):5-7.
doi: 10.1016/j.stem.2020.12.006.

Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming

Pradeep Reddy  1 , Sebastian Memczak  1 , Juan Carlos Izpisua Belmonte  2
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Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming

Pradeep Reddy et al. Cell Stem Cell. .
Free article

Abstract

The regeneration potential of axons projecting from retinal ganglion cells (RGCs) is lost shortly after birth. In Nature, Lu et al. (2020) demonstrate that epigenetic reprogramming of RGCs by overexpression of Oct4, Sox2, and Klf4 leads to axon regeneration and restoration of vision in a glaucoma model and aged mice.

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  • Reprogramming to recover youthful epigenetic information and restore vision.
    Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Lu Y, et al. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. Nature. 2020. PMID: 33268865 Free PMC article.

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