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Comment
. 2021 Jan 7;28(1):8-9.
doi: 10.1016/j.stem.2020.12.013.

Tipping the Scale: MYC Gains Weight in Fanconi Anemia Bone Marrow Failure Progression

Xavier Renaudin  1 , Filippo Rosselli  2
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Tipping the Scale: MYC Gains Weight in Fanconi Anemia Bone Marrow Failure Progression

Xavier Renaudin et al. Cell Stem Cell. .
Free article

Abstract

Fanconi anemia (FA) is an inherited syndrome of bone marrow failure (BMF) due to disrupted DNA repair. In this issue of Cell Stem Cell, Rodríguez et al. (2021) show that blood stem cells from FA patients have abnormal and inflammation-induced MYC expression, which promotes their proliferation in the face of increasing DNA damage.

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  • MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
    Rodríguez A, Zhang K, Färkkilä A, Filiatrault J, Yang C, Velázquez M, Furutani E, Goldman DC, García de Teresa B, Garza-Mayén G, McQueen K, Sambel LA, Molina B, Torres L, González M, Vadillo E, Pelayo R, Fleming WH, Grompe M, Shimamura A, Hautaniemi S, Greenberger J, Frías S, Parmar K, D'Andrea AD. Rodríguez A, et al. Cell Stem Cell. 2021 Jan 7;28(1):33-47.e8. doi: 10.1016/j.stem.2020.09.004. Epub 2020 Sep 29. Cell Stem Cell. 2021. PMID: 32997960 Free PMC article.

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