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Review
. 2021 Jan 6;26(2):252.
doi: 10.3390/molecules26020252.

Azadirachta indica A. Juss. In Vivo Toxicity-An Updated Review

Teresa M Braga  1 , Lídia Rocha  1 , Tsz Yan Chung  1 , Rita F Oliveira  1 , Cláudia Pinho  1 , Ana I Oliveira  1 , Joaquim Morgado  2   3 , Agostinho Cruz  1
Affiliations
Review

Azadirachta indica A. Juss. In Vivo Toxicity-An Updated Review

Teresa M Braga et al. Molecules. .

Abstract

The Neem tree, Azadirachta indica A. Juss., is known for its large spectrum of compounds with biological and pharmacological interest. These include, among others, activities that are anticancer, antibacterial, antiviral, and anti-inflammatory. Some neem compounds are also used as insecticides, herbicides, and/or antifeedants. The safety of these compounds is not always taken into consideration and few in vivo toxicity studies have been performed. The current study is a literature review of the latest in vivo toxicity of A. indica. It is divided in two major sections-aquatic animals toxicity and mammalian toxicity-each related to neem's application as a pesticide or a potential new therapeutic drug, respectively.

Keywords: Azadirachta indica; in vivo; toxicity.

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Conflict of interest statement

The authors declare no conflict of interest.

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