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. 2021 Jan-Feb;18(1):53-65.
doi: 10.21873/cgp.20241.

Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

Agne Pasvenskaite  1 , Rasa Liutkeviciene  2 , Greta Gedvilaite  2 , Alvita Vilkeviciute  2 , Vykintas Liutkevicius  3 , Virgilijus Uloza  3
Affiliations

Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

Agne Pasvenskaite et al. Cancer Genomics Proteomics. 2021 Jan-Feb.

Abstract

Background/aim: Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate.

Patients and methods: A total of 300 LSCC patients and 533 controls were included in the study. Genotyping was carried out using RT-PCR; IL-10 serum levels were analyzed by ELISA.

Results: Significant associations were identified between IL-10 rs1800871 variants and advanced stage of LSCC patient group in the codominant, recessive and additive models (OR=0.473, p=0.027; OR=0.510, p=0.040; and OR=0.733; p=0.037). Significant variants of IL-10 rs1800872 were determined in the codominant, recessive and additive models (OR=0.473, p=0.027; OR=0.510, p=0.040; and OR=0.733, p=0.037). The distribution of IL-10 SNPs genotypes did not impact LSCC patient survival rate (respectively, p=0.952; p=0.952; p=0.991).

Conclusion: IL-10:rs1800871 and rs1800872 SNPs are associated with advanced stage of LSCC. The genotypic distribution of IL-10 SNPs does not influence the survival rate of LSCC patients.

Keywords: IL-10; Laryngeal squamous cell carcinoma; gene polymorphism; levels; rs1800871; rs1800872; rs1800896; serum; survival rate..

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Conflict of interest statement

The Authors declare no potential conflicts of interest associated with this study.

Figures

Figure 1
Figure 1. Serum IL10 concentrations in controls and patients with LSCC.
Figure 2
Figure 2. Five-year survival rate according to the distribution of IL-10 rs1800871 and IL-10 rs1800872 genotypes.
Figure 3
Figure 3. Five-year survival rate according to the distribution of IL-10 rs1800896 genotypes.
See this image and copyright information in PMC

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References

    1. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017;67(1):31–50. doi: 10.3322/caac.21386. - DOI - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30. doi: 10.3322/caac.21332. - DOI - PubMed
    1. Wang N, Lv H, Huang M. Impact of gender on survival in patients with laryngeal squamous cell carcinoma: A propensity score matching analysis. Int J Clin Exp Pathol. 2020;13(3):573–58. - PMC - PubMed
    1. The Global Cancer Observatory 2018 Estimated cancer incidence, mortality and prevalence Wordwide in 2018. Lyon, International Agency for Research on Cancer, 2018. Available at: https://gco.iarc.fr/today/data/factsheets/cancers/14-Larynxfact-sheet.pdf [Last accessed on 15th November 2020]
    1. Shin JY, Truong MT. Racial disparities in laryngeal cancer treatment and outcome: A population-based analysis of 24,069 patients. Laryngoscope. 2015;125(7):1667–1674. doi: 10.1002/lary.25212. - DOI - PubMed

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