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. 2022 Jan;414(1):377-384.
doi: 10.1007/s00216-020-03098-2. Epub 2021 Jan 8.

Thermal stability of cannabinoids in dried cannabis: a kinetic study

Juris Meija  1 , Garnet McRae  2 , Christopher O Miles  3 , Jeremy E Melanson  2
Affiliations

Thermal stability of cannabinoids in dried cannabis: a kinetic study

Juris Meija et al. Anal Bioanal Chem. 2022 Jan.

Abstract

This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from - 20 to + 40 ∘C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.

Keywords: Bayesian kinetic modeling; Cannabis; Stability of cannabinoids.

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