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Review
. 2021 Aug;17(4):1194-1214.
doi: 10.1007/s12015-020-10086-7. Epub 2021 Jan 8.

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lacy E Lowry  1   2 , Maryanne C Herzig  2 , Barbara A Christy  3   4 , Richard Schäfer  5 , Shibani Pati  6 , Andrew P Cap  2   7 , James A Bynum  2   8   9
Affiliations
Review

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lacy E Lowry et al. Stem Cell Rev Rep. 2021 Aug.

Abstract

Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here.

Keywords: Cell therapy; Trauma.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Systemic responses and complications associated with severe traumatic injury
Fig. 2
Fig. 2
Cell types commonly used in cellular therapy applications, either as live cells or as a source for cellular products such as extracellular vesicles (EVs)
See this image and copyright information in PMC

References

    1. Prevention (2016) CfDCa, . Injury Prevention & Control. 10 Leading Causes of Death by Age Group United States-2016. [January 28, 2019]. Available from: https://www.cdc.gov/injury/wisqars/LeadingCauses.html.
    1. Pati S, Pilia M, Grimsley JM, Karanikas AT, Oyeniyi B, Holcomb JB, et al. Cellular therapies in trauma and critical care medicine: Forging new frontiers. Shock. 2015;44(6):505–523. doi: 10.1097/SHK.0000000000000482. - DOI - PMC - PubMed
    1. Howard JT, Kotwal RS, Santos-Lazada AR, Martin MJ, Stockinger ZT. Reexamination of a battlefield trauma golden hour policy. Journal of Trauma and Acute Care Surgery. 2018;84(1):11–18. doi: 10.1097/TA.0000000000001727. - DOI - PubMed
    1. Sakran JV, Greer SE, Werlin E, McCunn M. Care of the injured worldwide: trauma still the neglected disease of modern society. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2012;20:64. doi: 10.1186/1757-7241-20-64. - DOI - PMC - PubMed
    1. Committee on Trauma and Committee on Shock, Division of Medical Sciences, National Academy of Sciences, National Research Council. (1966). Accidental death and disability: the neglected disease of modern society. Washington (DC): National Academies Press (US). - PubMed

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