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. 2021 Jan 8;188(2):35.
doi: 10.1007/s00604-020-04642-8.

Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Subash Vetri Selvi #  1 , Adhimoorthy Prasannan #  2 , Shen-Ming Chen  3 , Adhisankar Vadivelmurugan  4 , Hsieh-Chih Tsai  5   6 , Juin-Yih Lai  4   7   8
Affiliations

Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Subash Vetri Selvi et al. Mikrochim Acta. .

Abstract

Two-dimensional (2D) MoS2core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L-glutathione and cystamine (L-GSH-MoS2-CYS) using ultrasonic frequency of 20-25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1-78.3 and 98.3-1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM-1 cm-2 was acquired at 0.48 V. The fabricated L-GSH-MoS2-CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated L-GSH-MoS2-CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability. Graphical abstract.

Keywords: Core-shell nanoparticle; Doxorubicin; Electrochemical sensors; Glutathione; Molybdenum disulfide; Ultrasonic assisted synthesis.

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