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. 1988 Feb 15;150(3):1155-61.
doi: 10.1016/0006-291x(88)90750-4.

Giant polypeptides of skeletal muscle titin: sedimentation equilibrium in guanidine hydrochloride

G P Kurzban  1 , K Wang
Affiliations

Giant polypeptides of skeletal muscle titin: sedimentation equilibrium in guanidine hydrochloride

G P Kurzban et al. Biochem Biophys Res Commun. .

Abstract

Titin has been purified from rabbit skeletal myofibrils in guanidine hydrochloride by gel filtration on Sephacryl S-1000. The sedimentation coefficients of denatured titin in 6 M guanidine hydrochloride are highly concentration dependent and follow the equation: 1/S = 0.241 + 0.302 A280. Equilibrium sedimentation studies indicate that the average molecular weight of titin polypeptides is 2.4 to 2.6 X 10(6).

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