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. 2021 Oct 29;56(6):660-668.
doi: 10.1093/alcalc/agaa138.

Heterogeneity in DSM-5 Symptom Criteria: Phenotypes of Alcohol Use Disorder in a Sample Seeking Alcohol Treatment

Junru Zhao  1 , Braden Linn  2 , Clara Bradizza  1 , Joseph Lucke  3 , Melanie Ruszczyk  1 , Paul Stasiewicz  1
Affiliations

Heterogeneity in DSM-5 Symptom Criteria: Phenotypes of Alcohol Use Disorder in a Sample Seeking Alcohol Treatment

Junru Zhao et al. Alcohol Alcohol. .

Abstract

Aims: This study sought to identify phenotypic variations among individuals with alcohol use disorder (AUD) that may, in part, help improve the effectiveness of existing AUD interventions.

Methods: Latent class analysis was conducted to examine the potential heterogeneity of AUD in a sample (N = 220; Mage = 51.19 years, standard deviation = 9.94; 37.7% female) of treatment-seeking participants diagnosed with AUD using DSM-5 criteria.

Results and conclusions: Three distinct patterns of responses to the 11 DSM-5 AUD symptoms emerged: Class 1 (n = 114, 51.8%), Class 2 (n = 78, 35.5%) and Class 3 (n = 28, 12.7%). The identified profiles were further differentiated by demographics, alcohol-related constructs, individual difference characteristics and diagnostic and treatment variables. The findings have implications for refining AUD assessment as well as optimizing personalized treatment.

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Figures

Fig. 1
Fig. 1
Profiles of AUD using conditional probabilities. Note. On the x-axis of the graph are the 11 AUD items and the conditional probability of endorsing each item is on the y-axis.
See this image and copyright information in PMC

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