Proteodynamics and aging of eukaryotic cells

Abstract

All aspects of each protein existence in the eukaryotic cells, starting from the pre-translation events, through translation, multiple different post-translational modifications, functional life and eventual proteostatic removal after loss of functionality and changes in physico-chemical properties, can be collectively called the proteodynamics. With aging, passing of time as well as accumulating effects of exposures, interactions and wearing-off lead to problems at each of the above mentioned stages, eventually leading to general malfunction of the proteome. This work briefly reviews and summarizes current knowledge concerning this important topic.

Keywords: Aging; Aging-Related diseases; Calpains; Inflammaging; Post-Translational modification of proteins; Proteodynamics; Proteostasis.