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Review
. 2020 Dec 30;42(6):825-830.
doi: 10.3881/j.issn.1000-503X.11534.

[Predictive Biomarkers of Immune-related Adverse Events Induced by Checkpoint Inhibitors in Malignancies]

[Article in Chinese]
Hui Tang  1 , Mei Guan  1 , Zhao Sun  1 , Chun Mei Bai  1
Affiliations
Review

[Predictive Biomarkers of Immune-related Adverse Events Induced by Checkpoint Inhibitors in Malignancies]

[Article in Chinese]
Hui Tang et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. .

Abstract

While immune checkpoint inhibitors(ICIs)are effective and promising treatments for a variety of malignancies,they also have safety concerns,especially the immune-related adverse events(irAEs).Unlike the side effects of traditional chemotherapy and targeted therapy,irAEs are adverse events caused by immune activation after ICIs treatment and thus may involve almost every system of the body.Therefore,biomarkers for predicting irAEs after ICIs treatment are urgently needed.Here we review the currently available predictive biomarkers of irAEs.

Keywords: biomarker; cancer; immune checkpoint inhibitors; immune-related adverse events.

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