Application of quercetin flavonoid based hybrid nanocomposites: A review

Abstract

Natural bioflavonoids are an essential component of dietary supplements possessing antimicrobial properties. Many of the bioflavonoids have resulted in positive antitumor, anticancer, antibacterial, antifungal, anti-inflammatory properties, but the efficacy remains low due to toxicity at the molecular level whereas antiviral property limits to negative. The synergistic link between nanoscience and flavonoid chemistry enhances the epidemiological properties of flavonoid and also diminish the antimicrobial resistivity (AMR) by forming their hybrid nanocomposites. Nanochemistry uses various nanocomposite and nanomaterials for biosensing the flavonoids and their delivery as a drug. The quercetin flavonoid and its derivatives such as rutin, and myricetin are used for sensing and drug delivery. Quercetin with 15Carbon-5Hydroxyl chemical scaffold has been explored for a few decades for the development of hybrid nanocomposite and nanomaterial with metallic as well as organic nano co-composites. This quercetin flavonoid based hybrid nanocomposites seemed to show a significant effect on In vitro and some animal model processes along with attenuating lipid peroxidation, platelet aggregation, and capillary permeability actions. This review mainly focused on the hybrid nanoscience of quercetin bioflavonoid and its application in numerous biological, material fields with a future perspective.

Keywords: Antimicrobial resistivity; Biomedical applications; Flavonoid; Nanocomposites; Quercetin.

Fig. 1

Classification of bioflavonoid backbones.

Scheme 1

Active sites of bioflavonol quercetin.

Fig. 2

illustrates the SEM image for quercetin NPs at two different magnification range [31]. [Reproduced with the permission from Elsevier].

Fig. 3

Illustrates the XRD of original quercetin (a), and quercetin nanocrystals at different concentration of 2 wt% (b), 5 wt% (c), 10 wt% (d), and 2 wt% after 90 days (e) respectively [34]. [Reproduced with permission from Elsevier].

Fig. 4

represents the thermal state of QCN at (A) room temperature (RT), (B) 125 °C, (C) 314 °C, and (D) TG/DSC curve of the quercetin under nitrogen atmosphere [33].[Reproduced with the permission from Elsevier].

Fig. 5

illustrates the FTIR spectra of the monomer (quercetin) and the polyuercetin [37]. [Reproduced with the permission from Elsevier].

Fig. 6

represents a schematic for a general representation of the encapsulation process.

Fig. 7

represents the schematic view for the use of quercetin hybrid nanocomposites to inhibit AMR.