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Observational Study
. 2020 Oct 8:37:144.
doi: 10.11604/pamj.2020.37.144.25802. eCollection 2020.

Predictors of AIDS-related death among adult HIV-infected inpatients in Kisangani, the Democratic Republic of Congo

Alliance Tagoto Tepungipame  1   2 , Serge Tonen-Wolyec  1   3 , Ginette Claude Kalla  4 , Eugeune Basandja Longembe  1 , Rachel Olonga Atike  1 , Joris Losimba Likwela  1 , Francois-Xavier Mbopi-Kéou  4   5 , Laurent Bélec  6 , Salomon Batina-Agasa  1
Affiliations
Observational Study

Predictors of AIDS-related death among adult HIV-infected inpatients in Kisangani, the Democratic Republic of Congo

Alliance Tagoto Tepungipame et al. Pan Afr Med J. .

Abstract

Introduction: Human Immunodeficiency Virus (HIV) infection continues to be a major public health concern in sub-Saharan Africa. We aimed to evaluate potential factors associated with AIDS-related death among adult HIV-infected inpatients in Kisangani, the Democratic Republic of the Congo (DRC).

Methods: this is a hospital-based retrospective, observational analysis carried out between 1st January 2019 and 31st March 2020 among inpatients HIV, at 12 facilities integrating the HIV prevention and care packages in Kisangani. Factors associated with AIDS-related death were analyzed using the logistic regression models.

Results: a total of 347 HIV-infected inpatients were included. Among those, the rate of AIDS-related death was 25.1% (95% CI: 20.8-29.9). The rates of AIDS-related death were lower among patients with a university education (aOR: 0.03 [95% CI: 0.00-1.0]) and higher among patients in WHO clinical stage 4 (aOR: 15.4 [6.8-27.8]), patients with poor highly active antiretroviral therapy (HAART) observance (aOR: 14.5 [2.3-40.4), and patients suffering from opportunistic infections (aOR: 9.3 [95% CI: 3.4-25.1]), including cryptococcal meningitis (aOR: 27 [95% CI: 6.0-125.7]) and viral infections associated with zona and Kaposi sarcoma (aOR: 4.8 [95% CI: 2.2-10.4]).

Conclusion: in our retrospective study on a large sample of inpatients hospitalized in Kisangani, classic causes of death were found. The association with the low level of education suggests that the economic level of the patients who die is a determining factor, difficult to correct. The identification of a limited number of other factors will allow a better medical management.

Keywords: AIDS-related death; Democratic Republic of the Congo; HIV; HIV-infected inpatients; predictors.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
flow chart showing the review of HIV registry, inclusion of HIV inpatients, and rate of AIDS-related death
Figure 2
Figure 2
clustered bars showing the causes of hospitalization of HIV-infected patients in Kisangani, DRC
See this image and copyright information in PMC

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