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. 2020 Dec 8:60:737-742.
doi: 10.1016/j.amsu.2020.11.088. eCollection 2020 Dec.

Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury

Sachraswaty Rachman Laidding  1 , Fonny Josh  1 , Francisca  2 , Muhammad Faruk  2 , Andi Sinapati Palissei  2 , Bayu Satria  2 , Warsinggih  2 , Agussalim Bukhari  3 , Muh Nassrum Massi  4 , Andi Asadul Islam  5
Affiliations

Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury

Sachraswaty Rachman Laidding et al. Ann Med Surg (Lond). .

Abstract

Introduction: The combination of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) is effective at increasing the concentration of growth factors including transforming growth factor-β (TGF-β). The increase in this growth factor is expected to accelerate the healing of burns. This study aims to determine the effect of giving a combination of SVFs and PRP on TGF-β levels in the healing process of deep dermal burns.

Methods: This was an experimental study in 64 rats using a post-test control group design consisting of 1 group of SVFs and PRP combination injection treatment group, 1 group given a topical combination of SVFs and PRP, 1 group given Vaseline, and 1 control group.

Results: There was a significant difference in TGF-β levels between the deep dermal burns group that was given a combination of SVFs and PRP injection and topical, the Vaseline group, and the control group with p-value <0.05.

Conclusion: The combination of SVFs and PRP increases the level of TGF-β in the healing process of deep dermal burns.

Keywords: Burn injury; Experimental research; Platelet-rich plasma; Stromal vascular fraction; TGF-β.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
Histopatological deep dermal burn model in our study.
Fig. 2
Fig. 2
Average changes in TGF-β levels in each treatment group.
Fig. 3
Fig. 3
Comparison of TGF-β levels between Groups C and D.
See this image and copyright information in PMC

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