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Review
. 2020 Dec 23:8:605134.
doi: 10.3389/fped.2020.605134. eCollection 2020.

Conservative Non-intervention Approach for Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants

Se In Sung  1 , Yun Sil Chang  1 , So Yoon Ahn  1 , Heui Seung Jo  1 , Misun Yang  1 , Won Soon Park  1
Affiliations
Review

Conservative Non-intervention Approach for Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants

Se In Sung et al. Front Pediatr. .

Abstract

While persistent patent ductus arteriosus (PDA) in preterm infants has been known to be associated with increased mortality and morbidities including bronchopulmonary dysplasia, and necrotizing enterocolitis, there is minimal evidence supporting their causal relationships, and most traditional medical and/or surgical treatments have failed to show improvements in these outcomes. As such, the pendulum has swung toward the conservative non-intervention approach for the management of persistent PDA during the last decade; however, the benefits and risks of this approach are unclear. In this mini review, we focused on whom, when, and how to apply the conservative non-intervention approach for persistent PDA, especially in extremely preterm infants.

Keywords: conservative management; extremely preterm infants; non-intervention; patent ductus arteriosus; premature infants.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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