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. 2020 Dec 11:7:594295.
doi: 10.3389/fmed.2020.594295. eCollection 2020.

Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review

Alaa M M El-Betany  1 , Enas M Behiry  2 , Mark Gumbleton  1 , Keith G Harding  3
Affiliations

Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review

Alaa M M El-Betany et al. Front Med (Lausanne). .

Abstract

The coronavirus disease (COVID-19) outbreak has presented enormous challenges for healthcare, societal, and economic systems worldwide. There is an urgent global need for a universal vaccine to cover all SARS-CoV-2 mutant strains to stop the current COVID-19 pandemic and the threat of an inevitable second wave of coronavirus. Carbon dioxide is safe and superior antimicrobial, which suggests it should be effective against coronaviruses and mutants thereof. Depending on the therapeutic regime, CO2 could also ameliorate other COVID-19 symptoms as it has also been reported to have antioxidant, anti-inflammation, anti-cytokine effects, and to stimulate the human immune system. Moreover, CO2 has beneficial effects on respiratory physiology, cardiovascular health, and human nervous systems. This article reviews the rationale of early treatment by inhaling safe doses of warmed humidified CO2 gas, either alone or as a carrier gas to deliver other inhaled drugs may help save lives by suppressing SARS-CoV-2 infections and excessive inflammatory responses. We suggest testing this somewhat counter-intuitive, but low tech and safe intervention for its suitability as a preventive measure and treatment against COVID-19. Overall, development and evaluation of this therapy now may provide a safe and economical tool for use not only during the current pandemic but also for any future outbreaks of respiratory diseases and related conditions.

Keywords: anti-COVID-19; anti-cytokine storm; antiviral; carrier gas composition; enhancer antiviral; improve COVID-19 symptoms; protect and improve organs function; suppression COVID-19 pandemic.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Graphical Abstract
Graphical Abstract
Precise control of the unique properties and intervention parameters of warmed humidified CO2 gas make it a promising anti-COVID-19 therapy for mitigation and suppression of SARS-CoV-2 infection.
Figure 1
Figure 1
Exceptional physical, biological, and medical properties of warmed humidified CO2 gas.
Figure 2
Figure 2
Suggested protocol for early and daily inhaling CO2 gas (2–4%) itself or composite with other COVID-19 inhaler medications could help in precaution and protection strategy to coexistence and adaptation with COVID-19 pandemic.
Figure 3
Figure 3
Suggested protocol for early inhaling CO2 gas (4–14%) itself or composite with other COVID-19 inhaler medications could save lives by disinfection and improve mild and moderate COVID-19 patient treatment.
Figure 4
Figure 4
Suggested supporting treatment protocol depending on time and duration of limited and convenient artificial hypercapnia acidosis (15–25%) that could help in saving more lives of severe COVID-19 patients.
See this image and copyright information in PMC

References

    1. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-vessel stroke as a presenting feature of covid-19 in the young. N Engl J Med. (2020) 382:e60 10.1056/NEJMc2009787 - DOI - PMC - PubMed
    1. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. . SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. (2020) 26:681–7. 10.1038/s41591-020-0868-6 - DOI - PMC - PubMed
    1. Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, et al. . Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. (2020) 582:557–60. 10.1038/s41586-020-2271-3 - DOI - PubMed
    1. Tang X, Wu C, Li X, Song Y, Yao X, Wu X, et al. On the origin and continuing evolution of SARS-CoV-2. Natl Sci Rev. (2020) 3:nwaa036 10.1093/nsr/nwaa036 - DOI - PMC - PubMed
    1. Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, et al. . COVID-19 infection: the perspectives on immune responses. Cell Death Differ. (2020) 27:1451–4. 10.1038/s41418-020-0530-3 - DOI - PMC - PubMed