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Review
. 2020 Dec 26:2020:8846982.
doi: 10.1155/2020/8846982. eCollection 2020.

The Role of Inflammation in Crohn's Disease Recurrence after Surgical Treatment

B Sensi  1 , L Siragusa  1 , C Efrati  2 , L Petagna  1 , M Franceschilli  1 , V Bellato  1 , A Antonelli  1 , C Arcudi  1 , M Campanelli  1 , S Ingallinella  1 , A M Guida  1 , A Divizia  1
Affiliations
Review

The Role of Inflammation in Crohn's Disease Recurrence after Surgical Treatment

B Sensi et al. J Immunol Res. .

Abstract

Introduction: Postoperative recurrence after surgery for Crohn's disease (CD) is virtually inevitable, and its mechanism is poorly known.

Aim: To review the numerous factors involved in CD postoperative recurrence (POR) pathogenesis, focusing on single immune system components as well as the immune system as a whole and highlighting the clinical significance in terms of preventive strategies and future perspectives.

Methods: A systematic literature search on CD POR, followed by a review of the main findings.

Results: The immune system plays a pivotal role in CD POR, with many different factors involved. Memory T-lymphocytes retained in mesenteric lymph nodes seem to represent the main driving force. New pathophysiology-based preventive strategies in the medical and surgical fields may help reduce POR rates. In particular, surgical strategies have already been developed and are currently under investigation.

Conclusions: POR is a complex phenomenon, whose driving mechanisms are gradually being unraveled. New preventive strategies addressing these mechanisms seem promising.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Systematic review methodology.
Figure 2
Figure 2
Pathogenesis of Crohn's disease recurrence. Created with https://BioRender.com
Figure 3
Figure 3
Pathophysiological excision for Crohn's (PEC). Created with https://BioRender.com
See this image and copyright information in PMC

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