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Case Reports
. 2020 Oct 17;6(1):224-227.
doi: 10.1016/j.ekir.2020.10.012. eCollection 2021 Jan.

Treatment of Concurrent Minimal Change Disease and Epstein Barr Virus-Driven Post-transplant Lymphoproliferative Disorder With Rituximab Following Hematopoietic Stem Cell Transplantation

Louise Ainley  1 , Steven Law  2 , Lauren Heptinstall  3 , Manuel Rodriguez-Justo  4 , Kirsty Thomson  1 , Ruth J Pepper  5
Affiliations
Case Reports

Treatment of Concurrent Minimal Change Disease and Epstein Barr Virus-Driven Post-transplant Lymphoproliferative Disorder With Rituximab Following Hematopoietic Stem Cell Transplantation

Louise Ainley et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Core biopsy of a right-sided cervical level 2 lymph node showing effacement of the architecture by a proliferation of immunoblasts, plasma cells, plasmacytoid cells, and medium-sized lymphocytes (a: hematoxylin-eosin, original magnification ×100; and b: hematoxylin-eosin, original magnification ×400). Mitotic features and Epstein-Barr virus–encoded small RNA-positive cells are also seen (a; small window).
Figure 2
Figure 2
Renal biopsy capturing 12 glomeruli, with no sclerosis, crescents, spikes, amyloid material, or duplications, and normal mesangial matrix and cell numbers. Immunohistochemistry was negative for IgG, IgA, and IgM; complement (C3 and C1q), BK virus, and Epstein-Barr virus. (a) Medium power image showing 3 morphologically normal glomeruli surrounded by well-preserved tubules (hematoxylin-eosin, original magnification ×20). (b) High-power image of a morphologically normal glomerulus (Periodic acid methenamine silver, original magnification ×40). (c) Electron micrograph showing a capillary loop with effacement of the podocyte foot processes (arrow) and a podocyte nucleus (arrowhead); no electron-dense deposits were found, and the glomerular basement membrane was morphologically normal (image courtesy of Leicester Royal Infirmary electron microscopy department, original magnification ×2000).
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References

    1. Hingorani S. Renal complications of hematopoietic-cell transplantation. N Engl J Med. 2016;374:2256–2267. - PubMed
    1. Beyar-Katz O., Davila E.K., Zuckerman T. Adult nephrotic syndrome after hematopoietic stem cell transplantation: renal pathology is the best predictor of response to therapy. Biol Blood Marrow Transplant. 2016;22:975–981. - PubMed
    1. Wong E., Lasica M., He S.Z. Nephrotic syndrome as a complication of chronic graft-versus-host disease after allogeneic haemopoietic stem cell transplantation. Intern Med J. 2016;46:737–741. - PubMed
    1. Brukamp K. Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease? Clin J Am Soc Nephrol. 2006;1:685–694. - PubMed
    1. Styczynski J., Gil L., Tridello G. Response to rituximab-based therapy and risk factor analysis in Epstein Barr Virus–related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Clin Infect Dis. 2013;57:794–802. - PubMed

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