Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics

Affiliations

¹ Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.

W Zhong et al. J Cell Signal. 2020 Dec.

. 2020 Dec;1(4):155-159.

doi: 10.33696/Signaling.1.024.

¹ Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.

No abstract available

Keywords: Akt; Ca2+; Chemotherapy; Emesis; Emetic nuclei; GSK-3; PI3K.

Conflict of interest statement

Conflicts of Interest We have no conflict of interest to declare.

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1. Adel N Overview of chemotherapy-induced nausea and vomiting and evidence-based therapies. The American Journal of Managed Care. 2017. September;23(14 Suppl):S259. - PubMed
1. Navari RM, Aapro M. Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting. New England Journal of Medicine. 2016. April 7;374(14):1356–67. - PubMed
1. Hesketh PJ. Chemotherapy-induced nausea and vomiting. New England Journal of Medicine. 2008. June 5;358(23):2482–94. - PubMed
1. Sanger GJ, Andrews PLR. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research. Frontiers in Pharmacology. 2018. September 4;9;913. - PMC - PubMed
1. Babic T, Browning KN. The role of vagal neurocircuits in the regulation of nausea and vomiting. European Journal of Pharmacology. 2014. January 5;722:38–47. - PMC - PubMed