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Review
. 2021 Mar;49(2):118-127.
doi: 10.1111/ceo.13892. Epub 2021 Jan 10.

Cataract and systemic disease: A review

Michael J Ang  1 , Natalie A Afshari  1
Affiliations
Review

Cataract and systemic disease: A review

Michael J Ang et al. Clin Exp Ophthalmol. 2021 Mar.

Abstract

We review the current literature regarding the risk factors for cataract and the association between cataract and systemic disease. Numerous epidemiologic studies have found that the risk factors for age-related cataract formation include age, sex, race and myopia. Modifiable risk factors include smoking, socioeconomic status and ultra-violet light exposure. Alcohol intake and nutritional status may play a role in cataract formation. Cataract has been associated with many systemic diseases mainly diabetes mellitus, hypertension, obesity, chronic kidney disease and autoimmune disease. Cataract is also a hallmark of many metabolic disorders and syndromes. These findings are important to help implement risk factor and lifestyle-modification strategies that can hopefully decrease the burden of global cataract blindness.

Keywords: age-related cataract; cataract; systemic disease.

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References

REFERENCES

    1. Lee CM, Afshari NA. The global state of cataract blindness. Curr Opin Ophthalmol. 2017;28(1):98-103.
    1. Khairallah M, Kahloun R, Bourne R, et al. Number of people blind or visually impaired by cataract worldwide and in world regions, 1990 to 2010. Invest Ophthalmol Vis Sci. 2015;56(11):6762-6769.
    1. Hutnik CM, Nichols BD. Cataracts in systemic diseases and syndromes. Curr Opin Ophthalmol. 1999;10(1):22-28.
    1. Negahban K, Chern K. Cataracts associated with systemic disorders and syndromes. Curr Opin Ophthalmol. 2002;13(6):419-422.
    1. Khanna R, Pujari S, Sangwan V. Cataract surgery in developing countries. Curr Opin Ophthalmol. 2011;22(1):10-14.

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