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Review
. 2020 Nov-Dec;34(6 Suppl. 1):19-26.

Probiotics in the add-on treatment of otitis media in clinical practice

M Gelardi  1 , I La Mantia  2 , L Drago  3 , G Meroni  3 , S E Aragona  4 , G Cupido  5 , C Vicini  6 , C Berardi  7 , G Ciprandi  8 ; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S, Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N, Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A, Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F, Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R, Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A, Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F, Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E, Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M, Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G, Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A  9
Affiliations
  • PMID: 33426862
Free article
Review

Probiotics in the add-on treatment of otitis media in clinical practice

M Gelardi et al. J Biol Regul Homeost Agents. 2020 Nov-Dec.
Free article

Abstract

Otitis media (OM) affects the middle ear and is typically characterized by earache. OM may be classified as acute (AOM) or chronic (COM), based on symptom duration. OM may be clinically suspected, but the diagnosis is usually confirmed by the otoscopy. Antibiotic therapy is frequently used in clinical practice. However, antibiotics often induce intestinal and respiratory dysbiosis associated with some clinical problems. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).

Keywords: acute; antibiotic therapy; chronic; dysbiosis; otitis media; probiotics.

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