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Review
. 2021 Mar 1;16(5):397-408.
doi: 10.1002/asia.202001440. Epub 2021 Feb 2.

The Emergence of Palladium-Catalyzed C(sp3 )-H Functionalization of Free Carboxylic Acids

Animesh Das  1 , Biplab Maji  1
Affiliations
Review

The Emergence of Palladium-Catalyzed C(sp3 )-H Functionalization of Free Carboxylic Acids

Animesh Das et al. Chem Asian J. .

Abstract

Palladium-catalyzed directing group assisted C-H bond activation has emerged as a powerful tool in synthetic organic chemistry. However, only recently, among various directing groups, widely available carboxylate moiety is recognized as a versatile candidate for the regioselective transformations. Notably, palladium-catalyzed carboxylate directed C(sp3 )-H bond activation and diverse functionalization is highly challenging and has gained huge attention for its versatile applications. Mono- and bidentate ligands have proven to be useful for accelerating the C(sp3 )-H bond activation step, which helps to control reactivity and selectivity (including enantioselectivity). In this Minireview, we discuss the recent progress made in palladium-catalyzed C(sp3 )-H bond functionalization reactions for the construction of C-C and C-Heteroatom bonds with the direction of free carboxylic acid.

Keywords: Carboxylic acids; C−H bond activation; Directing group free strategy; Palladium; Weak coordination.

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