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. 2021 Apr 1;96(4):E103-E105.
doi: 10.1002/ajh.26091. Epub 2021 Jan 28.

Ruxolitinib in adult patients with secondary hemophagocytic lymphohistiocytosis

Philip S Boonstra  1 , Asra Ahmed  2 , Samuel A Merrill  3 , Ryan A Wilcox  2
Affiliations

Ruxolitinib in adult patients with secondary hemophagocytic lymphohistiocytosis

Philip S Boonstra et al. Am J Hematol. .
No abstract available

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Conflict of interest statement

Disclosure of conflicts of interest

We declare no competing interests.

References

    1. Locatelli F, Jordan MB, Allen C, Cesaro S, Rizzari C, Rao A, Degar B, Garrington TP, Sevilla J, Putti MC, Fagioli F, Ahlmann M, Dapena Diaz JL, Henry M, De Benedetti F, Grom A, Lapeyre G, Jacqmin P, Ballabio M, de Min C. Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. N Engl J Med 2020;382:1811–1822. - PubMed
    1. Das R, Guan P, Sprague L, Verbist K, Tedrick P, An QA, Cheng C, Kurachi M, Levine R, Wherry EJ, Canna SW, Behrens EM, Nichols KE. Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood 2016;127:1666–1675. - PMC - PubMed
    1. Ahmed A, Merrill SA, Alsawah F, Bockenstedt P, Campagnaro E, Devata S, Gitlin SD, Kaminski M, Cusick A, Phillips T, Sood S, Talpaz M, Quiery A, Boonstra PS, Wilcox RA. Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial. The Lancet Haematology 2019;6:e630–e637. - PMC - PubMed
    1. Wilcox RA. Janus Family kinase (JAK) inhibitors in HLH and severe COVID-19. Am J Hematol 2020. - PubMed
    1. Bergsten E, Horne A, Arico M, Astigarraga I, Egeler RM, Filipovich AH, Ishii E, Janka G, Ladisch S, Lehmberg K, McClain KL, Minkov M, Montgomery S, Nanduri V, Rosso D, Henter JI. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study. Blood 2017;130:2728–2738. - PMC - PubMed

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