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Meta-Analysis
. 2021 Jan 8;100(1):e24101.
doi: 10.1097/MD.0000000000024101.

Effect of sodium-dependent glucose transporter inhibitors on glycated hemoglobin A1c after 24 weeks in patients with diabetes mellitus: A systematic review and meta-analysis

Mao-Bing Chen  1 , Hua Wang  2 , Qi-Han Zheng  1 , Hua-Lan Xu  2 , Wei-Yan Cui  2
Affiliations
Meta-Analysis

Effect of sodium-dependent glucose transporter inhibitors on glycated hemoglobin A1c after 24 weeks in patients with diabetes mellitus: A systematic review and meta-analysis

Mao-Bing Chen et al. Medicine (Baltimore). .

Abstract

Background: To evaluate dapagliflozin, canagliflozin, empagliflozin, ertugliflozin, and sotagliflozin according to their effect on the glycated hemoglobin A1c (HbA1c) level in patients with type 2 diabetes mellitus.

Methods: The Web of Science, PubMed, Cochrane Library, EMBASE, and Clinical Trials databases were electronically searched to collect randomized controlled trials of patients with type 2 diabetes mellitus through June 2020. Two researchers independently screened and evaluated the obtained studies and extracted the outcome indexes. RevMan 5.3 software was used to perform the meta-analysis and to create plots.

Results: Finally, 27 studies were selected and included in this study. The meta-analysis results showed that sodium-dependent glucose transporter (SGLT) inhibitors significantly reduced the HbA1c level in patients with type 2 diabetes mellitus. However, these results were highly heterogeneous, so we conducted a subgroup analysis. The results of the subgroup analysis suggested that by dividing populations into different subgroups, the heterogeneity of each group could be reduced.

Conclusions: SGLT inhibitors had a good effect on the HbA1c level in patients with type 2 diabetes mellitus, but there might be differences in the efficacy of SGLT inhibitors in different populations. It is hoped that more studies will be conducted to evaluate the efficacy and safety of SGLT inhibitors in different populations.

Registration number: CRD42020185025.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
PubMed database retrieval strategy and PRISMA flow diagram.
Figure 2
Figure 2
Forest plot comparing the SGLT inhibitors versus the placebo on HbA1c. HbA1c = glycated hemoglobin A1c, SGLT = sodium-dependent glucose transporter.
Figure 3
Figure 3
Mechanism of action of the SGLT protein in cells. SGLT = sodium-dependent glucose transporter.
See this image and copyright information in PMC

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