Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008-2011

Abstract

The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1-Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = - 0.302) and women (r = - 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.

Figure 1

Flow chart of the study. DXA, Dual-energy X‐ray absorptiometry; KNHANES, Korea National Health and Nutrition Examination Survey; TyG index triglyceride-glucose index.

Figure 2

Prevalence of low muscle mass according to quartiles of the TyG index. TyG index triglyceride-glucose index.

Figure 3

Scatter plot of the TyG index with ALM/weight in (a) men and (b) women. ALM appendicular lean mass; TyG index triglyceride-glucose index.