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Comment
. 2021 Feb;18(2):245-246.
doi: 10.1038/s41423-020-00595-3. Epub 2021 Jan 11.

COVID-19 and flu: conserved or specific immune signature?

Christophe Paget  1 , François Trottein  2
Affiliations
Comment

COVID-19 and flu: conserved or specific immune signature?

Christophe Paget et al. Cell Mol Immunol. 2021 Feb.

Erratum in

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Local and systemic responses during COVID-19 and influenza infections. Conserved and specific immune pathways (cell subsets, transcription factors and cytokines) potentially involved in the pathogenesis were identified at the systemic level. Further work is needed to analyze specific and common immune traits in the lungs during COVID-19 and influenza infections
See this image and copyright information in PMC

Comment on

References

    1. Zhu L, et al. Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients. Immunity. 2020;53:685–696.e3. doi: 10.1016/j.immuni.2020.07.009. - DOI - PMC - PubMed
    1. Bastard P, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;23:370. - PMC - PubMed
    1. Lee JS, et al. Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19. Sci. Immunol. 2020;10:5. - PMC - PubMed
    1. Wilk AJ, et al. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat. Med. 2020;26:1070–1076. doi: 10.1038/s41591-020-0944-y. - DOI - PMC - PubMed
    1. Veras FP, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J. Exp. Med. 2020;07:217. - PMC - PubMed