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. 2021 Jul;479(1):3-11.
doi: 10.1007/s00428-020-03005-1. Epub 2021 Jan 12.

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants

Arnaud de la Fouchardiere  1 , Willeke Blokx  2 , Léon C van Kempen  3 , Boštjan Luzar  4 , Sophie Piperno-Neumann  5   6 , Susana Puig  7   8   9 , Llucia Alos  8   10 , Eduardo Calonje  11 , Daniela Massi  12 ; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Affiliations

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants

Arnaud de la Fouchardiere et al. Virchows Arch. 2021 Jul.

Abstract

The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular tools, both in the setting of general pathology labs and expert centers. Moreover, recommendations regarding the re-excision and clinical follow-up are given to support decision-making in multidisciplinary tumor boards.

Keywords: BAP-1 inactivated nevus; Deep penetrating nevus; Intermediate melanocytic tumors; MELTUMP; Melanocytoma; Melanoma variants; Pigmented epithelioid melanocytoma; Spitz tumors.

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References

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