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Review
. 2021 Mar 1;84(3):245-247.
doi: 10.1097/JCMA.0000000000000485.

Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

Anna F Y Li  1   2 , Chia-Lin Wang  3 , Hsiao-Yun Tai  3 , Yun-Ju Fu  3 , Fu-Ting Tsai  3 , Yi-Ching Tsai  3 , Yu-Ling Ko  3 , Mei-Jane Li  3 , Chiou-Chyn Lin  3 , Tai-Jay Chang  3   4   5
Affiliations
Review

Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

Anna F Y Li et al. J Chin Med Assoc. .

Abstract

The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.

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Conflict of interest statement

Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.

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