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Review
. 2021 Jan;66(1):R15-R21.
doi: 10.1530/JME-20-0239.

Hepatic metabolic regulation by nuclear factor E4BP4

Zifeng Zhao  1   2 , Lei Yin  2 , Feihua Wu  1 , Xin Tong  2
Affiliations
Review

Hepatic metabolic regulation by nuclear factor E4BP4

Zifeng Zhao et al. J Mol Endocrinol. 2021 Jan.

Abstract

Discovered as a b-ZIP transcription repressor 30 years ago, E4 promoter-binding protein 4 (E4BP4) has been shown to play critical roles in immunity, circadian rhythms, and cancer progression. Recent research has highlighted E4BP4 as a novel regulator of metabolisms in various tissues. In this review, we focus on the function and mechanisms of hepatic E4BP4 in regulating lipid and glucose homeostasis, bile metabolism, as well as xenobiotic metabolism. Finally, E4BP4-specific targets will be discussed for the prevention and treatment of metabolic disorders.

Keywords: E4BP4; glucose; insulin; lipid; metabolism.

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Conflict of interest statement

Declaration of Interest

All the authors declare no financial interest or potential conflict of interest.

Figures

Figure 1:
Figure 1:
Schematic of E4BP4 functional domains.
Figure 2:
Figure 2:
Overview of metabolic actions of E4BP4 in the liver. Hepatic E4BP4 expression and activity are likely to be sensitive to the cycle of fasting/refeeding, hormones, stress signals, and the circadian clock. Hepatic E4BP4 regulates lipid metabolism, glucose metabolism, bile acid metabolism, and xenobiotic metabolism to impact the whole body homeostasis.
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